VILON

What Is It?

Vilon, classified as G protein-coupled receptors (GPCRs) mediate a wide range of signalling processes and are targeted by one third of the drugs in clinical use1. Although most GPCR-targeting therapeutics are small molecules2, the endogenous ligands for many GPCRs are peptides (comprising 50 or fewer amino acids), which suggests that this class of molecule could be therapeutically useful.

Approach

Naturally occurring peptides, however, do not typically make good therapeutics. The development of peptides as drugs has been limited by poor pharmacokinetics (short half-life, rapid degradation and high levels of clearance) and by a lack of oral bioavailability due to a combination of low gastrointestinal stability and poor permeability. Therefore, strategies need to be developed that can address these aspects before most peptides can become effective medicines.

Legal Disclaimer

Only legal application for peptides is for research purposes. Any claim found on this website beyond the realm of research application is for entertainment purposes only.

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