FGL

What is FGL?

FGL(L) is a peptide with neurotrophic and memory enhancing properties. FGL peptide is a variant of the natural neural cell adhesion molecule. Neural cell adhesion molecule (NCAM) is a membrane-bound glycoprotein expressed on the surface of neuronal and glial cells. FGL(L) was directly created as a fibroblast growth factor receptor agonist.
FG loop (FGL) peptide, that is derived from the second F3 module of NCAM has been found to activate FGFR1.

Benefits

Activating the NCAM–FGFR signaling pathways result in increased neurite outgrowth and survival and leads to its effects in memory. In addition to its effects on memory, FGL was found to have a positive impact on the healing of neuronal tissues subjected to ischemia by decreasing oxidative stress-induced neuronal cell death. FGL was also demonstrated to affect neuropathological symptoms related to Alzheimer’s disease by inhibiting neuronal degeneration and death.

Effects

Its potential effect on memory and neurodegenerative disease progression have excited many people and it was awarded a 60 million dollar grant in 2016 for further exploration. In addition to its effects on neurodegenerative disease, it also has been viewed as a targeted treatment for TBI, stroke, depression, and general improvement of cognitive function.

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